Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Fatigue
ADR ID BADD_A01626
ADR Hierarchy
08      General disorders and administration site conditions
08.01      General system disorders NEC
08.01.01      Asthenic conditions
08.01.01.002      Fatigue
Description A disorder characterized by a state of generalized weakness with a pronounced inability to summon sufficient energy to accomplish daily activities. [CTCAE] The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli. [MeSH]
MedDRA Code 10016256
MeSH ID D005221; D005221; D005221
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Enervation | Exhaustion | Exhaustion due to excessive exertion | Exhaustion due to exposure | Fatigability | Fatigability generalized | Fatigability lumbar | Fatigability of knees | Fatigue | Fatigue extreme | Fatiguability | Lassitude | Loss physical strength | Prostration | TATT | Tired all the time | Tired and heavy | Tired out | Tiredness | Washed-out | Weariness | Worn out | Fatigue aggravated | Depressive weariness | Fatigueability generalised | Chronic fatigue | Fatiguability generalised
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Epidermal growth factor receptorP00533T59328
Receptor tyrosine-protein kinase erbB-2P04626T14597
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00730Dronedarone--
BADD_D00732Droxidopa0.060271%
BADD_D00733Dulaglutide--
BADD_D00734Duloxetine0.119274%
BADD_D00735Duloxetine hydrochloride--
BADD_D00736Dutasteride--
BADD_D00738Ecallantide--
BADD_D00742Eculizumab--
BADD_D00743Edetate calcium disodium--
BADD_D00745Edetic acid--
BADD_D00749Efavirenz--
BADD_D00754Elazop--
BADD_D00755Eletriptan--
BADD_D00757Eliglustat0.128166%
BADD_D00758Elosulfase alfa--
BADD_D00759Eltrombopag0.048464%
BADD_D00760Eltrombopag olamine--
BADD_D00761Eluxadoline--
BADD_D00762Elvitegravir--
BADD_D00765Empagliflozin--
BADD_D00766Emtricitabine--
BADD_D00767Enalapril maleate--
BADD_D00768Enalaprilat--
BADD_D00771Enfuvirtide--
BADD_D00773Entacapone--
BADD_D00774Entecavir--
BADD_D00775Enzalutamide0.532495%
BADD_D00776Eovist--
BADD_D00779Epi-kal2--
BADD_D00782Epinephrine--
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